FIBROBLASTIC RETICULAR CELLS OF THE LYMPHOID TISSUES MODULATE T CELL ACTIVATION THRESHOLD DURING HOMEOSTASIS VIA HYPERACTIVE CYCLOOXYGENASE-2/PROSTAGLANDIN E2 AXIS

Abstract Fibroblastic reticular cells (FRCs) in the T cell zone of lymph nodes (LNs) are pivotal for T cell survival, mobility, and peripheral tolerance.Here, we demonstrate that during homeostasis, FRCs also suppress T cell activation Ball - Junior Tops - Baselayer via producing high level of prostaglandin E2 (PGE2) due to their thousands-fold hig

A commercial low-density polyethylene (LDPE) which is produced by the polymerization process of ethylene in the presence of initiators in a long tubular reactor is the most widely used in polymer industry.The highly exothermic nature of the LDPE polymerization process and the heating-cooling prerequisite in the tubular reactor can lead to various p

In the context of rapid urbanization and extreme climate change globally, balancing ecological resources and economic development for land spatial planning has become one of the pressing issues that need to be addressed.This study proposes a composite model to construct a spatial ecological security pattern.It identifies restoration areas with diff

Umzimkhulu, previously Transkei, is a small KwaZulu-Natal town.AmaBhaca Umzimkhulu residents speak isiBhaca, a dialect of isiXhosa that is mutually intelligible with isiZulu and siSwati.IsiBhaca is not official in South Africa.Most Umzimkhulu residents are amaBhaca, although education, health, religious, and government institutions use isiZulu and